Sjögren's disease & overlap diseases
Prevalence, incidence and mortality of interstitial lung disease in patients with Sjogren disease: data from the prospective observational “EMERGE” study
Authors' conclusion
ILD can be identified in a high number of SjD patients, inducing a significant impairment in survival. The ILD extent, but not HRCT pattern of ILD, represents the main predictor of mortality.
Study context
- Population
- Unselected consecutive Sjögren disease (SjD) patients referred to the centre
- Participants
- 257 patients
- Exposure
- SjD patients with vs without interstitial lung disease (ILD)
- ILDn = 61
- Outcome
- Prevalence, incidence and mortality of SjD-ILD
Methodological detailsobservational, consecutive patients, single-centre
- Observational
- Consecutive patients
- Single-centre
Main finding
As reported in the abstract
Prevalence of ILD at enrolment
ILD prevalence (61/257)
23.7 %
ILD incidence, new cases per 100 patients/year (3 new cases)
0.41
Observational data: associations, not effects.
Further findings
| Outcome | ILD | Without ILD | P value |
|---|---|---|---|
| Overall survival · mean follow-up 42.6 ± 14.6 months | 66.5 % ± 11.7 | 88.4 % ± 5.5 | P < 0.001 |
- Overall survival — Deaths during follow-up (21 patients)
- 8.2 %
Factors associated with ILD (multivariate)
- Direct association with male sex, age at SjD diagnosis and ESR >40 mm; inverse with sicca syndrome
Predictors of mortality
- Fibrotic pattern associated with worse survival; no difference by radiologic pattern
- Anti-SSA protective; age at SjD diagnosis and ILD extent at high-resolution computed tomography (HRCT) associated with increased mortality
Original publication
Prevalence, incidence and mortality of interstitial lung disease in patients with Sjogren disease: data from the prospective observational “EMERGE” study. Semin Arthritis Rheum. Published 22 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →