Sjögren's disease & overlap diseases
Impact of smoking status on Sjögren’s disease diagnosis and phenotype: results from a cohort study with matched population controls
Authors' conclusion
Smoking was negatively associated with SjD diagnosis compared with sicca, but not population controls.
Study context
- Population
- Adults referred for suspected SjD to the OASIS cohort, 2014–2023smoking data for 85.0%
- Exposure
- SjD vs non-Sjögren's sicca syndrome and matched population controls, by smoking status
- SjDn = 317
- Siccan = 170reference
- Outcome
- SjD diagnosis (SjD meeting 2016 classification criteria vs sicca) by smoking status
Methodological detailsmatched population controls, multivariate logistic and linear regression
- Matched population controls
- Multivariate logistic and linear regression
Main finding
As reported in the abstract
Odds ratio
0.37
95% CI 0.15–0.92
By group
Observational data: associations, not effects.
Further findings
| Outcome | Sicca | Population controls | P value |
|---|---|---|---|
| Ever-smoking vs population controls | 49.6% | 39.1% | P = 0.049 |
Phenotype in never smokers
- Higher IgG levels in never smokers
- P = 0.003
- More frequent biological ESSDAI activity in never smokers
- P = 0.038
- Smoking exposure correlated with reduced IgG, RF levels and seropositivity, independent of DMARD use
Ever-smoking vs population controls
- SjD did not show higher ever-smoking rates than population controls
Original publication
Impact of smoking status on Sjögren’s disease diagnosis and phenotype: results from a cohort study with matched population controls. Rheumatology (Oxford). Published 24 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →