Sjögren's disease & overlap diseases
Hydroxychloroquine dose-dependently reduces the risk of incident diabetes in primary Sjögren syndrome patients on glucocorticoids: a nationwide population-based cohort study
Authors' conclusion
Our study demonstrated that HCQ exposure significantly reduces the risk of developing diabetes in patients with pSS. While higher doses of glucocorticoids are associated with an increased diabetes risk, concurrent HCQ use mitigates this risk in a dose-dependent manner.
Study context
- Population
- Patients diagnosed with pSS, Taiwan's National Health Insurance Research Database, 2006–2015497 developed diabetes mellitus (DM)
- Exposure
- Hydroxychloroquine (HCQ) users vs HCQ nonusers
- HCQ usersn = 4,874
- HCQ nonusersn = 2,437reference
- Outcome
- Incident (new-onset) DM
Methodological detailsnationwide population-based, multivariate and stratified analyses, Kaplan-Meier method, Cox proportional hazard regression
- Nationwide population-based
- Multivariate and stratified analyses
- Kaplan-Meier method
- Cox proportional hazard regression
Main finding
As reported in the abstract
Incident DM · average follow-up 4.89 years
Each group vs HCQ nonusersAdjusted hazard ratio (95% CI)
HCQ 151-350 cDDD
0.600(0.454–0.794)
HCQ ≥ 351 cDDD
0.326(0.246–0.433)
Observational data: associations, not effects.
Further findings
DM risk with high-dose GC (≥ 151 cumulative defined daily dose (cDDD))
| aHR (95% CI) | ||
|---|---|---|
| High-dose GC (≥ 151 cDDD) | 1.833 (1.410–2.383) | |
| 0.512Adjusted hazard ratio (log scale) |
DM risk with high-dose HCQ (> 350 cDDD), incl. with high-dose GC (≥ 151 cDDD)
| aHR (95% CI) | P value | ||
|---|---|---|---|
| High-dose HCQ (> 350 cDDD) | 0.632 (0.421–0.948) | P < 0.01 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Hydroxychloroquine dose-dependently reduces the risk of incident diabetes in primary Sjögren syndrome patients on glucocorticoids: a nationwide population-based cohort study. Arthritis Res Ther. Published 16 April 2025. doi:10.
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