Sjögren's disease & overlap diseases
Concomitant Sjögren’s disease in patients with neuromyelitis optica spectrum disorder (NMOSD): impacts on neurologic disease severity and recurrence
Authors' conclusion
NMOSD patients with SjD manifested more severe disease at attack and relapsed earlier than those without SjD.
Study context
- Population
- NMOSD patients serologically positive for AQP4-IgG, single tertiary centrederivation 108, validation 47
- Participants
- 155 participants
- Exposure
- NMOSD with Sjogren's disease (SjD) vs NMOSD without SjD
- NMOSD with SjDn = 70
- NMOSD without SjDn = 85reference
- Outcome
- Predictors of coexisting SjD and performance of a predictive nomogram
Methodological detailssingle tertiary-centre cohort, predictive nomogram, derivation and validation groups (7:3), logistic regression
- Single tertiary-centre cohort
- Predictive nomogram
- Derivation and validation groups (7:3)
- Logistic regression
Main finding
As reported in the abstract
Independent predictors of coexisting SjD; nomogram AUC
- Age upon recruitment
- P = 0.002
- Expanded Disability Status Scale (EDSS) score
- P = 0.023
- Blood white blood cell (WBC) count
- P = 0.049
- Rheumatoid factor (RF)
- P = 0.049
- Anti-SSA (Ro) antibody positivity
- P < 0.001
- Anti-SSB (La) antibody positivity
- P = 0.012
- Nomogram AUC (95% CI), derivation cohort
- 0.95 (0.89, 1.00)
- Nomogram AUC (95% CI), validation cohort
- 0.91 (0.79, 1.00)
Observational data: associations, not effects.
Further findings
Relapse and time to EDSS score 4.0 (survival curve analysis)
- EDSS score in NMOSD with SjD associated with clinical relapse; reached EDSS 4.0 earlier than those without SjD
Original publication
Concomitant Sjögren’s disease in patients with NMOSD: impacts on neurologic disease severity and recurrence. Arthritis Res Ther. Published 5 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →