Sjögren's disease & overlap diseases
Comparison and clinical analysis of tissue-specific autoantibodies levels in primary Sjögren's disease and other connective tissue diseases
Authors' conclusion
Anti-CA6, anti-PSP and anti-SP1 antibodies show diagnostic value in pSjD, with elevated IgG levels reflecting disease progression, histopathological damage, and distinct autoantibody interactions, implicating their pathogenic contributions.
Study context
- Population
- Patients with primary Sjögren's disease (pSjD), patients with other connective tissue diseases, and healthy controls
- Participants
- 60 / 30 / 30
- Exposure
- pSjD vs disease controls with other connective tissue diseases (CTDs) vs healthy controls
- pSjDn = 60
- Disease controls (DC)n = 30reference
- Healthy controls (HC)n = 30reference
- Outcome
- Serum levels of anti-PSP, anti-SP1 and anti-CA6 antibodies
Methodological detailscase-control comparison, chemiluminescent immunoassays
- Case-control comparison
- Chemiluminescent immunoassays
Main finding
As reported in the abstract
Serum anti-CA6 IgG, anti-PSP IgG/IgA and anti-SP1 IgG levels
- These antibodies have a certain predictive accuracy in pSjD
- pSjD vs DC and HC: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Anti-CA6 IgG and anti-PSP IgG by anti-SSA52KD(Ro52)/SSA60KD(Ro60)/SSB(La) status (subgroup)Anti-Ro52/Ro60/La positive vs Seronegative · higher levels in positive subgroups | P < 0.05 |
Clinical correlations of immunoglobulin G (IgG) subtype of anti-CA6, anti-PSP and anti-SP1
- Positive correlation with erythrocyte sedimentation rate (ESR) and IgG
Anti-CA6 IgG and anti-PSP IgG by severity of labial gland pathology
- Levels increased significantly with severity of labial gland pathology
- P < 0.05
Anti-CA6 and anti-PSP IgG by anti-centromere antibody (ACA) positivity (subgroup)
- ACA positivity linked to lower levels of anti-CA6 and anti-PSP IgG
Original publication
Comparison and clinical analysis of tissue-specific autoantibodies levels in primary Sjögren's disease and other connective tissue diseases. Clin Exp Rheumatol. Published 27 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →