Sjögren's disease & overlap diseases
Organ-specific autoimmunity in primary Sjögren’s disease
Authors' conclusion
One-third of patients with primary SjD had OSA, with endocrine involvement being the most common. OSA may precede, follow, or accompany the diagnosis of SjD, and is not associated with higher disease activity.
Study context
- Population
- Patients with primary Sjögren's disease (SjD) according to ACR/EULAR criteria
- Participants
- 328 patients
- Exposure
- Patients with organ-specific autoimmunity (OSA) vs those without OSA
- Outcome
- Prevalence of organ-specific autoimmunity (OSA)
Methodological detailslogistic regression analysis
- Logistic regression analysis
Main finding
As reported in the abstract
Prevalence of OSA
OSA
37.9%
122 events
- Most frequent: autoimmune hypothyroidism
- 56
- Primary biliary cholangitis (PBC)
- 28
- Autoimmune hepatitis
- 8
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Variables associated with OSA (logistic regression)OSAvs Without OSAconcomitant/post-SjD diagnosis OSAvs no OSAanti-Ro/SSA | 0.44 (0.20–0.97) | P = 0.04 | |
| Variables associated with OSA (logistic regression)OSAvs Without OSAconcomitant/post-SjD diagnosis OSAvs no OSADisease duration | 1.03 (1.005–1.06) | P = 0.01 | |
| Variables associated with OSA (logistic regression)OSAvs Without OSAconcomitant/post-SjD diagnosis OSAvs no OSAUse of AZA | 2.12 (1.14–3.84) | P = 0.01 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Variables associated with OSA (logistic regression)OSA vs Without OSA · use of MTX · concomitant/post-SjD diagnosis OSA vs no OSA | 0.32 (0.55–0.73) | P = 0.007 |
Timing of OSA relative to SjD
- Preceded SjD
- 37 (30.3%)
- Followed SjD
- 62 (50.8%)
- Concomitant
- 23 (18.8%)
Original publication
Organ-specific autoimmunity in primary Sjögren’s disease. Scand J Rheumatol. Published 23 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →