Sjögren's disease & overlap diseases
Clinical and serological differences of an Italian Sjögren's disease cohort according to three geographic macro-area localisations
Authors' conclusion
This study provides the first evidence of geo-epidemiological differences among Italian SjD patients, highlighting how geographic origin is associated with disease phenotype and comorbidities.
Study context
- Population
- Sjögren's disease (SjD) patients (2016 ACR/EULAR criteria) in the Italian SjD Study Group registry; median 53 (42–63) years at diagnosis, 95% females
- Participants
- 1,231 patients
- Exposure
- SjD patients by geographic macro-area: North vs Centre vs South
- Outcome
- Epidemiologic, serologic, clinical features and comorbidities according to geographical origin
Methodological detailsmulticentre, registry-based, consecutively included
- Multicentre
- Registry-based
- Consecutively included
Main finding
As reported in the abstract
Age at diagnosis
- South: higher frequency of activity in constitutional and articular domains, lower in biological domains
- p<0.001 for all
- Hypertension and hypercholesterolaemia more prevalent in Centre; obesity more common in South vs North
- p<0.001
Observational data: associations, not effects.
Original publication
Clinical and serological differences of an Italian Sjögren's disease cohort according to three geographic macro-area localisations. Clin Exp Rheumatol. Published 10 June 2025. doi:10.
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