Sjögren's disease & overlap diseases
Efficacy of N-acetylcysteine for treating dryness symptoms of Sjögren's disease: randomised placebo-controlled double-blind clinical study
Authors' conclusion
However, our well-designed study provides novel evidence demonstrating its inefficacy for improving dryness symptoms or reducing oxidative stress.
Study context
- Population
- Adult Sjögren's disease (SjD) females with low disease activity
- Participants
- 60 adult SjD females
- Comparison
- N-acetylcysteine (NAC) 1,200 mg/day orally vs placebo
- Primary endpoint
- Efficacy of NAC for relieving dryness symptoms (EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI), Ocular Surface Disease Index (OSDI), Xerostomia Inventory (XI), Leicester Cough Questionnaire (LCQ), salivary flow, Schirmer's test)
- Follow-up
- D30 and D90
Methodological detailsplacebo-controlled, double-blind
- Placebo-controlled
- Double-blind
Primary result
As reported in the abstract
Dryness symptoms (ESSPRI, XI, OSDI, LCQ, Schirmer's test, stimulated salivary flow, ESSDAI, topical/systemic treatments)
- No significant differences between NAC and placebo (p>0.05)
Further findings
| Outcome | P value |
|---|---|
| Unstimulated salivary flow · D90Significantly higher in the placebo group | P = 0.018 |
| NAC blood concentrations · D30 and D90NAC vs Placebo · D30; significantly higher in the NAC group | P = 0.018 |
| NAC blood concentrations · D30 and D90NAC vs Placebo · D90; significantly higher in the NAC group | P < 0.001 |
| Decrease ≥1 in ESSPRI · D30 and D90NAC vs Placebo · D30 · further analysis | P = 0.045 |
| Decrease ≥1 in ESSPRI · D30 and D90NAC vs Placebo · D90; result not found · further analysis | P = 0.696 |
Thiobarbituric acid reactive substances (TBARS) and glutathione
- No differences found
Original publication
Efficacy of N-acetylcysteine for treating dryness symptoms of Sjögren's disease: randomised placebo-controlled double-blind clinical study. Clin Exp Rheumatol. Published 13 July 2024. doi:10.
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