Sjögren's disease & overlap diseases
Detection of anti-calreticulin antibody in the sera of Chinese patients with primary Sjögren syndrome
Authors' conclusion
The present study identified an autoimmune antibody, anti-CALR antibody, as a good autoimmune biomarker for sero-negative pSjS.
Study context
- Population
- Chinese patients with primary Sjögren syndrome and healthy controls
- Participants
- 120 vs 54
- Exposure
- Primary Sjögren syndrome (pSjS) patients vs healthy controls
- pSjSn = 120
- Healthy controlsn = 54reference
- Outcome
- Prevalence of anti-calreticulin (CALR) antibody
Methodological detailscell-based indirect immunofluorescence, two-dimensional electrophoresis and LC-MS/MS, enzyme-linked immunosorbent assay (ELISA)
- Cell-based indirect immunofluorescence
- Two-dimensional electrophoresis and LC-MS/MS
- ELISA
Main finding
As reported in the abstract
Anti-CALR antibody positivity
Observational data: associations, not effects.
Further findings
Anti-CALR antibody positivity by serostatus (subgroups of pSjS)
%
- anti-SSA positive
- 40.85
- anti-SSB positive
- 53.85
- Sero-negative
- 14.7
Association of anti-CALR antibody with clinical manifestations
- Weight loss
- P = 0.045
- Vasculitis
- P = 0.031
Correlation of anti-CALR antibody with laboratory parameters
- Erythrocyte sedimentation rate (ESR)
- r = 0.056, p = 0.021
- KL-6
- r = 0.121, p = 0.035
- IgG
- r = 0.097, p < 0.001
- IgG2
- r = 0.142, p = 0.022
- IgG3
- r = 0.287, p < 0.001
- Fibrinogen
- r = 0.084, p = 0.016
- D-Dimer
- r = 0.086, p = 0.012
- Fibrinogen degradation production
- r = 0.150, p = 0.002
Salivary gland CALR expression vs lymphocyte infiltration
- Correlation
- r = 0.7076, p = 0.0034
Original publication
Detection of anti-calreticulin antibody in the sera of Chinese patients with primary Sjögren syndrome. Semin Arthritis Rheum. Published 15 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →