Sjögren's disease & overlap diseases
Diagnostic potential of soluble and membrane-bound inducible T-cell co-stimulator in Sjögren's disease
Authors' conclusion
Soluble ICOS levels and ICOS expression on CD4+ T cells are elevated in SjD patients when they enter diagnostic process.
Study context
- Population
- Newly diagnosed and established Sjögren's disease (SjD) patients, sicca and healthy controls
- Participants
- 39 / 10 / 30 / 27
- Comparison
- Newly diagnosed SjD vs established SjD, sicca and healthy controls
- Newly diagnosed SjDn = 39
- Established SjDn = 10
- Siccan = 30reference
- Healthy controlsn = 27reference
- Outcome
- Soluble ICOS (serum, ELISA), ICOS on CD4+ and CD8+ T cells and ICOSL on B cells and monocytes (flow cytometry); associations with clinical features and diagnostic potential
Performance
As reported in the abstract
Soluble ICOS and ICOS on CD4+ T cells
- Soluble ICOS and ICOS on CD4+ T cells significantly elevated in newly diagnosed SjD
- ROC analysis: strong ability of soluble ICOS and CD4+ T-cell ICOS to differentiate SjD at diagnostic entry from sicca and healthy controls
Further findings
Associations with clinical features
- Soluble ICOS positively associated with RF
- CD4+ T-cell ICOS positively correlated with gamma globulins and positively associated with anti-Ro antibodies and RF
Original publication
Diagnostic potential of soluble and membrane-bound inducible T-cell co-stimulator in Sjögren's disease. Clin Exp Rheumatol. Published 3 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →