Sjögren's disease & overlap diseases
Risk of heart disease in neonates born to mothers with primary Sjögren’s syndrome: a multicenter retrospective study
Authors' conclusion
Maternal pSS, especially with high disease activity, elevates the risk of neonatal heart disease, highlighting the need for careful monitoring during pregnancy.
Study context
- Population
- Newborns of mothers with primary Sjögren's syndrome (pSS) treated between January 2015 and May 2024
- Participants
- 169 newborns
- Exposure
- Newborns of pSS mothers with vs without heart disease
- Heart diseasen = 49
- No heart diseasen = 120reference
- Outcome
- Cardiac disorders in neonates of mothers with pSS
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Neonatal heart disease
Heart disease
49
events
Observational data: associations, not effects.
Further findings
Neonatal outcomes in newborns with vs without cardiac conditions
- Higher rates of premature birth with cardiac conditions (P = 0.002)
- Lower birth weight with cardiac conditions (P = 0.012)
- Increased neonatal asphyxia (P = 0.009), brain injury (P < 0.001) and neonatal infections (P < 0.001)
Maternal outcomes, mothers of babies with vs without heart conditions
- More umbilical cord abnormalities (P = 0.002) and threatened preterm labor (P = 0.008)
Original publication
Risk of heart disease in neonates born to mothers with primary Sjögren’s syndrome: a multicenter retrospective study. Rheumatology (Oxford). Published 27 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →