Sjögren's disease & overlap diseases
Development of salivary gland organoids derived from patient biopsies: a functional model of Sjögren’s disease
Authors' conclusion
We successfully developed SGOs from LSGBs of SjD patients, allowing long-term culture and faithfully recapitulating the disease phenotype.
Study context
- Population
- Sjögren's disease (SjD) patients and sicca controls; organoids from labial salivary gland biopsies
- Participants
- 13 vs 15
- Comparison
- SjD-derived vs sicca control-derived salivary gland organoids
- SjDn = 13
- Controlsn = 15reference
- Outcome
- Organoid formation, long-term culture viability and self-renewal capacity of SGOs from labial salivary gland biopsies (LSGBs)
Methodological detailspatient-derived salivary gland organoids, long-term culture
- Patient-derived salivary gland organoids
- Long-term culture
Main finding
As reported in the abstract
Salivary gland organoids (SGOs) formed in both groups, demonstrating long-term culture viability and comparable self-renewal capacity
3.3 ± 1.7 months
Original publication
Development of salivary gland organoids derived from patient biopsies: a functional model of Sjögren’s disease. Ann Rheum Dis. Published 20 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →