Sjögren's disease & overlap diseases
Association between interleukin-12 p40 subunit and risk of primary Sjögren’s disease: a Mendelian randomization study
Authors' conclusion
This study provides genetic evidence that IL-12p40 has a causal role in primary Sjögren's disease pathogenesis. Our data suggest that decreasing levels of IL-12p40 may be deleterious.
Study context
- Population
- Genetic association data: protein studies (sample size 3301 to 54,306) and 3232 cases of pSS and 17,481 controls3,232 cases · 17,481 controls
- Comparison
- Genetically predicted levels of circulating IL-12/IL-23 pathway proteins (IL12A, IL12B, IL12Rβ1, IL12Rβ2, IL23R) and risk of pSS
- Outcome
- Risk of pSS
Methodological detailstwo independent exposure datasets, Wald ratio or inverse variance weighted methods, colocalization and pleiotropy-robust sensitivity analyses
- Two independent exposure datasets
- Wald ratio or inverse variance weighted methods
- Colocalization and pleiotropy-robust sensitivity analyses
Main finding
As reported in the abstract
pSS per SD decrease in genetically predicted IL-12p40 (IL12B)
OR, exposure dataset 1
0.79
95% CI 0.68–0.93P-value = 0.004
OR, exposure dataset 2
0.86
95% CI 0.78–0.95P-value = 0.003
Further findings
IL-12Rβ2 and IL-23R
- Neither met the threshold P-value after MR analyses (P-value < 0.01) for colocalization assessment
IL12A
- No variants met prerequisite thresholds for weak instrument bias
Original publication
Association between interleukin-12 p40 subunit and risk of primary Sjögren’s disease: a Mendelian randomization study. Rheumatology (Oxford). Published 2 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →