Sjögren's disease & overlap diseases
Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study
Authors' conclusion
SS had significant causal relationships with lymphomas, prostate cancer, and endometrial cancer, and suggestive evidence of association was found in liver and bile duct cancer and cancer of urinary tract, indicating that SS may play a vital role in the incidence of these malignancies.
Study context
- Population
- European population; GWAS summary statistics, sample size 1080 to 372,373sample size 1080 to 372,373
- Comparison
- Genetically predicted Sjögren's syndrome (SS) vs nine types of cancers
- Outcome
- Causal effect of SS on nine types of cancers (IVW)
Methodological detailspublic GWAS summary statistics, European population, inverse variance weighted (IVW) method, Bonferroni-corrected threshold P < 0.0031, sensitivity analysis
- Public GWAS summary statistics, European population
- IVW method
- Bonferroni-corrected threshold P < 0.0031
- Sensitivity analysis
Main finding
As reported in the abstract
Causal effect of SS on cancers (IVW)
SSEstimate (95% CI)P value
Increased risk
OR (lymphomas) 1.0010(1.0005–1.0015)
P = 0.0002Reduced risk
OR (prostate cancer) 0.9972(0.9960–0.9985)
P = 2.45 × 10-5Reduced risk
OR (endometrial cancer) 0.9414(0.9158–0.9676)
P = 1.65 × 10-5Suggestive association
OR (liver and bile duct cancer) 0.9999(0.9997–1.0000)
P = 0.0291Suggestive association
OR (cancer of urinary tract) 0.9996(0.9992–1.0000)
P = 0.0281Further findings
Mediation by well-accepted cancer risk factors
- Causal effects between SS and cancers not mediated by well-accepted risk factors of cancers
Reverse direction: cancers on SS
- No evidence of causal relationship for cancers on SS
Original publication
Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study. Arthritis Res Ther. Published 15 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →