Sjögren's disease & overlap diseases
Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis
Authors' conclusion
This study found no obvious evidence that serum vitamin D level is causally associated with SS risks or vice versa.
Study context
- Population
- Genome-wide association studies (GWAS) summary statistics: serum vitamin D levels (UK Biobank) and Sjogren's syndrome (SS) (FinnGen)SS: 2495 cases, 414,262 controls
- Comparison
- Genetically predicted serum vitamin D levels and SS risk, in both directions
- Outcome
- Causal effect of serum 25(OH)D levels on SS risk (IVW)
Methodological detailstwo-sample GWAS summary statistics, inverse-variance weighted (IVW) main analysis, MR-Egger and weighted median supplementary analyses, sensitivity analyses: Cochran's Q test, MR-PRESSO, MR-Egger intercept test, leave-one-out test, Vitamin D GWAS sample size = 417,580 (UK Biobank); SS GWAS sample size = 416,757 (FinnGen)
- Two-sample GWAS summary statistics
- Inverse-variance weighted (IVW) main analysis
- MR-Egger and weighted median supplementary analyses
- Sensitivity analyses: Cochran's Q test, MR-PRESSO, MR-Egger intercept test, leave-one-out test
- Vitamin D GWAS sample size = 417,580 (UK Biobank); SS GWAS sample size = 416,757 (FinnGen)
Main finding
As reported in the abstract
- No significant causal effect of serum 25(OH)D on SS risk: OR
- 0.9824
- 95% CI
- 0.7130 to 1.3538
- P
- P = 0.9137
Further findings
Reverse direction: causal effect of SS on serum vitamin D levels
- No evidence of causal effect of SS on serum vitamin D: β
- 0.0076
- 95% CI
- - 0.0031 to 0.0183
- P
- P = 0.1640
Original publication
Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis. Arthritis Res Ther. Published 15 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →