Sjögren's disease & overlap diseases
Autoantibodies identify primary Sjögren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B
Authors' conclusion
We identified antigenic targets of the autoantibody response in SS that may be useful for identifying up to half of Ro seronegative SS cases.
Study context
- Population
- Primary Sjögren's syndrome, including anti-Ro/SS-A negative cases; discovery dataset n=30 Sjögren's syndrome (SS), n=15 HC; independent rheumatology practice cohort n=38 Ro+, n=36 Ro-, n=10 HCvalidation dataset
- Participants
- 46 / 50 / 42 / 54
- Comparison
- SS vs healthy and other disease controls
- Ro+ SSn = 46
- Ro- SSn = 50
- HCn = 42reference
- Other disease (OD)n = 54
- Outcome
- Autoantibodies identifying anti-Ro/SS-A negative primary SS
Methodological detailsproof-of-concept, discovery and validation datasets, random forest machine learning
- Proof-of-concept
- Discovery and validation datasets
- Random forest machine learning
Main finding
As reported in the abstract
Binding to ≥1 of the novel antigens
| Group | Value | Specificity |
|---|---|---|
| Ro- SS | 54% | 100% |
| Ro+ SS | 37% | 100% |
Value
Ro- SS54%
Ro+ SS37%
Specificity
Ro- SS100%
Ro+ SS100%
- Novel autoantibody specificities in SS plasma
- 12
- Novel specificities detected in both discovery and validation datasets
- 11
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Machine learning (30 novel specificities) for identifying Ro- SS | Ro- SS AUC 0.79 (95% CI 0.64 to 0.93) |
Independent cohort: non-canonical antigens bound by Ro- sera
- Non-canonical antigens bound by sera from Ro- cases
- 17
Ro+ SS parotid saliva autoantibodies
- Bound Ro60, Ro52, La/SS-B and muscarinic receptor 5
Original publication
Autoantibodies identify primary Sjögren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B. Ann Rheum Dis. Published 5 May 2023. doi:10.
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