Sjögren's disease & overlap diseases
Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome
Authors' conclusion
Local exposure to extreme climate-related hazards plays a role in modulating the presentation of Sjögren across countries concerning the age at which the disease is diagnosed, the frequency of dryness, and the degree of systemic activity.
Study context
- Population
- Patients with primary SjD (2002/2016 criteria) from 23 countries in the OECD climate rankings
- Participants
- 16,042 patients23 countries
- Exposure
- Countries among the top 10 most exposed to each climate-related hazard vs no-risk countries
- Outcome
- Sjögren's phenotype at diagnosis: age at diagnosis, dry eyes, dry mouth and overall ESSDAI score
- Follow-up
- At diagnosis
Methodological detailsmultinational database, OECD climate-related hazard rankings, climatic variables dichotomous (top 10 most exposed countries)
- Multinational database
- OECD climate-related hazard rankings
- Climatic variables dichotomous (top 10 most exposed countries)
Main finding
As reported in the abstract
Phenotype at diagnosis by climate-hazard exposure
- Lower frequency of dry eyes with exposure to wind threats, river flooding and coastal flooding
- p<0.0001 for the three variables
- Lower frequency of dry mouth with exposure to river flooding
- p<0.0001
- Lower frequency of dry mouth with exposure to coastal flooding
- p<0.0001
- Higher mean ESSDAI with exposure to extreme temperature vs no-risk countries
- p<0.0001
- Higher mean ESSDAI with exposure to river flooding vs no-risk countries
- p<0.0001
- Lower mean ESSDAI with exposure to wind threats vs no-risk countries
- p<0.0001
- Lower mean ESSDAI with exposure to coastal flooding vs no-risk countries
- p<0.0001
Observational data: associations, not effects.
Original publication
Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome. Clin Exp Rheumatol. Published 28 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →