Sjögren's disease & overlap diseases
Disease evolution and organ damage accrual in patients with stable UCTD: a long-term monocentric inception cohort
Authors' conclusion
Although less significantly impacted than in patients with SLE, in the long-term UCTDs can accumulate organ damage and evolve into defined connective tissue diseases.
Study context
- Population
- Inception cohort of patients with stable UCTD, single centreinception cohort
- Participants
- 141 participants
- Exposure
- sUCTD vs age-matched and sex-matched patients with systemic lupus erythematosus (SLE)
- sUCTDn = 141
- Outcome
- Disease evolution and damage accrual
- Follow-up
- 1, 5 and 10 years
Methodological detailslongitudinal, inception cohort, monocentric, age-matched and sex-matched SLE comparison cohort, partial least square regression, Nelson-Aalen analysis
- Longitudinal
- Inception cohort
- Monocentric
- Age-matched and sex-matched SLE comparison cohort
- Partial least square regression
- Nelson-Aalen analysis
Main finding
As reported in the abstract
Evolved to a definite CTD
11.3%
Median time from first symptom to evolution to definite CTD
11 years
IQR 6–25
At least one item of organ damage (SLICC/DI)
27.3%
Mean SLICC/DI score
1.19±0.46
Observational data: associations, not effects.
Further findings
Mean survival without damage
Probability without damage · 10 years
P = 0.015
- Probability without damage: values as printed: 62% and 23% in SLE and sUCTD, respectively
Treatment at last visit (sUCTD)
- On GC
- 10%
- On immunosuppressive therapy
- 6%
Baseline variables associated with damage (partial least square (PLS) analysis)
- Age at diagnosis and age at first symptoms related to damage at 1 year
- Not taking antimalarials and taking immunosuppressants associated with damage at 5 years
Original publication
Disease evolution and organ damage accrual in patients with stable UCTD: a long-term monocentric inception cohort. RMD Open. Published 25 April 2024. doi:10.
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