Sjögren's disease & overlap diseases
Nailfold videocapillaroscopy findings and associations with organ involvement in mixed connective tissue disease
Authors' conclusion
We identified three NVC patterns in MCTD patients. 'Scleroderma pattern' was associated with presence of skin sclerosis and digital ulcers. Severe capillary loss was significantly associated with the presence of ILD.
Study context
- Population
- Patients with mixed connective tissue disease (MCTD) fulfilling one of three sets of classification criteria, Rheumatology Department, Cochin Hospital, Paris, FranceNailfold videocapillaroscopy (NVC) images for 40
- Participants
- 51 patients
- Exposure
- Normal vs Non-specific microangiopathy vs Scleroderma pattern
- Outcome
- NVC abnormalities in MCTD
Methodological detailssingle-centre, two independent observers
- Single-centre
- Two independent observers
Main finding
As reported in the abstract
NVC patterns
Observational data: associations, not effects.
Further findings
| Outcome | Scleroderma pattern | P value |
|---|---|---|
| Skin sclerosis, scleroderma pattern vs other patterns | 9/18 events | P = 0.008 |
| Digital ulcers, scleroderma pattern vs other patterns | 6/18 events | P = 0.017 |
| Number of capillaries, ILD vs no ILD | P = 0.039 | |
| ILD by severe reduction of capillary density (≤4/mm)Severe reduction (≤4/mm) vs No severe reduction | P = 0.002 | |
| Neoangiogenesis, ILD vs no ILD | P = 0.034 |
- Skin sclerosis, scleroderma pattern vs other patterns: Other patterns 5/32 events
- Digital ulcers, scleroderma pattern vs other patterns: Other patterns 2/32 events
- Number of capillaries, interstitial lung disease (ILD) vs no ILD: ILD 4.80 ± 1.87
- Number of capillaries, ILD vs no ILD: No ILD 6.03 ± 1.47
- ILD by severe reduction of capillary density (≤4/mm): Severe reduction (≤4/mm) 5/7 events
- ILD by severe reduction of capillary density (≤4/mm): No severe reduction 5/33 events
- Neoangiogenesis, ILD vs no ILD: ILD 6/13 events
- Neoangiogenesis, ILD vs no ILD: No ILD 4/27 events
ILD by severe reduction of capillary density (≤4/mm)
- Association independent of 'scleroderma pattern' and skin sclerosis
Original publication
Nailfold videocapillaroscopy findings and associations with organ involvement in mixed connective tissue disease. Clin Exp Rheumatol. Published 27 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →