Sjögren's disease & overlap diseases
The abnormal expression of peripheral blood CD4+ T lymphocyte subsets are correlated with primary Sjögren's syndrome complicated with haematological involvement
Authors' conclusion
An immunological mechanism potentially implicated in the development of pSS-HI may be the elevation of IL-10 and the reduction of peripheral blood CD4+ T cell subsets (particularly Treg cells) and serum IL-4 levels.
Study context
- Population
- Patients with primary Sjögren's syndrome (pSS) with and without haematological involvement and healthy controls, Second Hospital of Shanxi Medical University
- Participants
- 43 / 94 / 40
- Exposure
- pSS with haematological involvement vs pSS without haematological involvement vs healthy controls
- pSS-HIn = 43
- pSS-non-HIn = 94reference
- Healthy controls (HCs)n = 40
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- pSS-HI vs pSS-non-HI: more skin involvement, higher anti-SSA positivity, elevated IgA, IgG and ESR
- Number of all lymphocyte subsets lower in pSS-HI than pSS-non-HI
- Proportion of Th2 cells higher in pSS-HI than pSS-non-HI
- pSS-HI: elevated IL-10 and decreased IL-4 vs pSS-non-HI
- IL-10 significantly correlated with numbers of total T, CD4+ T, CD8+ T, NK, Th1, Th2 and Th17 cells
- Possible protective factors for pSS-HI: numbers of Treg and CD4+ T cells; possible risk factors: IgA and number of Th2 cells
Observational data: associations, not effects.
Original publication
The abnormal expression of peripheral blood CD4+ T lymphocyte subsets are correlated with primary Sjögren's syndrome complicated with haematological involvement. Clin Exp Rheumatol. Published 23 February 2024. doi:10.
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