Sjögren's disease & overlap diseases
Regional brain function study in patients with primary Sjögren’s syndrome
Authors' conclusion
PSS patients experience notable changes in regional brain function, as evidenced by alterations in both static and dynamic brain indicators.
Study context
- Population
- Primary Sjögren's syndrome (pSS) patients and healthy controls selected with stringent inclusion and exclusion criteria
- Participants
- 68 vs 69
- Exposure
- pSS vs healthy controls
- pSSn = 68
- Healthy controls (HCs)n = 69reference
- Outcome
- Differences in static and dynamic fractional amplitude of low-frequency fluctuation (fALFF) and region homogeneity (ReHo) between pSS and HCs
Methodological detailscase-control, rs-fMRI
- Case-control
- rs-fMRI
Main finding
As reported in the abstract
Regional brain function (rs-fMRI static and dynamic indices), pSS vs HCs
- Increased sfALFF in right supplementary motor area in pSS
- Significantly decreased static ReHo (sReHo) in left orbital media frontal gyrus, left caudate nucleus and right precuneus lobe in pSS
- Significantly increased dfALFF in left supplementary motor area in pSS
- Significantly increased dynamic ReHo (dReHo) in right dorsolateral superior frontal gyrus in pSS
Observational data: associations, not effects.
Further findings
Correlation of sReHo in right precuneus lobe with NCT-A scores
- Negative correlation
- P = 0.005
Correlation of dReHo in right dorsolateral superior frontal gyrus with DST scores
- Negative correlation
- P = 0.007
Original publication
Regional brain function study in patients with primary Sjögren’s syndrome. Arthritis Res Ther. Published 23 April 2025. doi:10.
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