Sjögren's disease & overlap diseases
Alteration of innate lymphoid cell homeostasis mainly concerns salivary glands in primary Sjögren’s syndrome
Authors' conclusion
Altered ILC homeostasis mainly concerns salivary glands in pSS. Most ILCs in MSGs consist of the ILC3 subset, located at the periphery of lymphocytic infiltrates. The ILC3 subset is more abundant in smaller infiltrates and in recently diagnosed pSS.
Study context
- Population
- Patients with primary Sjögren's syndrome (pSS), healthy controls and sicca controls
- Exposure
- pSS vs healthy controls (HCs) and vs sicca controls
- Outcome
- Frequency of ILC subsets in PB and their quantity and location in MSGs
Methodological detailsflow cytometry, immunofluorescence assay
- Flow cytometry
- Immunofluorescence assay
Main finding
As reported in the abstract
- In peripheral blood (PB), frequency of ILC subsets did not differ between pSS and HCs
- Circulating ILC1 increased in pSS with positive anti-SSA antibodies
- Circulating ILC3 reduced in pSS with glandular swelling
- In minor salivary glands (MSGs), ILC3 number higher in lymphocytic-infiltrated than non-infiltrated tissue in pSS and normal glandular tissue in sicca controls
- ILC3 preferentially located at periphery of infiltrates; more abundant in small infiltrates of recently diagnosed pSS
Observational data: associations, not effects.
Original publication
Alteration of innate lymphoid cell homeostasis mainly concerns salivary glands in primary Sjögren’s syndrome. RMD Open. Published 25 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →