Sjögren's disease & overlap diseases
Increasing the number of minor salivary glands from patients with Sjögren's disease improves the diagnostic and measurement precision of the histological focus score
Authors' conclusion
For continuous FS values, a larger number of MSGs (eg, 6) will increase reproducibility further and reduce clinical trial sample size requirements.
Study context
- Population
- Simulated patients with Sjögren's disease undergoing minor salivary gland (MSG) biopsy
- Comparison
- Different numbers of MSGs per biopsy
- Outcome
- Reproducibility: absolute difference between 2 within-patient FS measurements
Methodological detailsMonte Carlo, Monte Carlo simulations, MSG number varied (range, 2-7)
- Monte Carlo
- Monte Carlo simulations
- MSG number varied (range, 2-7)
Main finding
As reported in the abstract
2 glands
1.05
median · SD 0.25
7 glands
0.52
median · SD 0.12
Further findings
| Outcome | 2 glands | ≥5 glands | 7 glands |
|---|---|---|---|
| Probability of a simulated patient receiving a FS ≥1Median | 0.67 | 0.77 | — not stated in the abstract |
| Sample size per group for 80% power to detect a 40% FS reduction | 62 | — not stated in the abstract | 25 |
— not stated in the abstract
Original publication
Increasing the number of minor salivary glands from patients with Sjögren's disease improves the diagnostic and measurement precision of the histological focus score. Ann Rheum Dis. Published 17 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →