Sjögren's disease & overlap diseases
Associations of local bone involvement with disease activity, damage and functional disability in Sjögren's disease: A cross-sectional study
Authors' conclusion
This study shows a higher prevalence of bone erosions in SjD than previously described, particularly in older, postmenopausal women.
Study context
- Population
- Female patients with sjögren's disease (SjD) aged 18–65 years meeting ACR/EULAR 2016 criteria, without osteoporosis medication or other bone or autoimmune diseases, quaternary hospital in Brazil368 screened
- Participants
- 106 patients
- Outcome
- Bone erosions (and osteophytes) on HR-pQCT in 2nd and 3rd MCP and PIP joints and their association with clinical parameters
Methodological detailssingle-centre (quaternary hospital), high-resolution peripheral quantitative computed tomography (HR-pQCT), logistic regression and generalised linear models, July 2022 to October 2023
- Single-centre (quaternary hospital)
- HR-pQCT
- Logistic regression and generalised linear models
- July 2022 to October 2023
Main finding
As reported in the abstract
Bone erosions on HR-pQCT
- Prevalence of bone erosions (predominantly 3rd metacarpal head)
- 56.7 %
- Mean erosion volume
- 5.71 mm³
- Osteophytes
- 7.2 %
- Erosion volume increase per year of age
- 7 %
- Erosion volume, postmenopausal vs premenopausal women (fold increase)
- 3.54
Observational data: associations, not effects.
Original publication
Associations of local bone involvement with disease activity, damage and functional disability in Sjögren's disease: A cross-sectional study. Semin Arthritis Rheum. Published 30 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →