Sjögren's disease & overlap diseases
Association of visceral adipose tissue with inflammation and functional impairment in women with Sjögren's disease
Authors' conclusion
Elevated VAT levels in SjD are associated with increased disease activity, a higher prevalence of synovitis, and greater functional disability, suggesting that VAT may contribute to the functional impairment observed in SjD.
Study context
- Population
- Women with primary Sjögren's Disease (SjD) meeting ACR/EULAR 2016 classification criteria, tertiary care clinic (mean age 50.5±9.3 years; BMI 28.2±5.6 kg/m²; median disease duration 8 years)
- Participants
- 100 female patients
- Exposure
- Highest vs lower visceral adipose tissue (VAT) tertiles in women with SjD
- Outcome
- Association of VAT with inflammation, disease activity and functional impairment
Methodological detailssingle tertiary care clinic, VAT tertiles, comparison with healthy controls, multiple regression models
- Single tertiary care clinic
- VAT tertiles
- Comparison with healthy controls
- Multiple regression models
Main finding
As reported in the abstract
Synovitis prevalence by VAT tertile
P = 0.041
- Highest VAT tertile: lower handgrip strength
- P = 0.025
- Highest VAT tertile: higher HAQ scores
- P < 0.001
- VAT mass correlated with obesity
- P < 0.001
- VAT mass correlated with functional disability
- P = 0.002
- VAT mass correlated with ESSPRI
- P = 0.01
Observational data: associations, not effects.
Further findings
VAT levels by menopausal status
- Postmenopausal patients had significantly higher VAT levels than premenopausal patients
- P = 0.005
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of visceral adipose tissue with inflammation and functional impairment in women with Sjögren's disease. Clin Exp Rheumatol. Published 18 January 2025. doi:10.
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