Sjögren's disease & overlap diseases
Mortality in Patients With Sjögren Disease: A Prospective Cohort Study Identifying Key Predictors
Main finding · Overall mortalityResult — go to the resultStandard mortality ratio 1.7Authors' conclusion
This study found a significantly increased mortality risk in SjD, with infections, malignancies, and CVD as leading causes of death.
Study context
- Population
- Patients with Sjögren disease (SjD) (2002 American-European Consensus Group criteria) from the prospective, multicentre SjögrenSER Prospective cohort
- Participants
- 314 patients
- Exposure
- SjD cohort vs age- and sex-matched general population
- SjDn = 314
- Outcome
- Overall mortality
- Follow-up
- Median 9.5 (IQR 9.2-9.9) years
Methodological detailsmulticentre, SMR vs age- and sex-matched general population, Cox proportional hazards models
- Multicentre
- SMR vs age- and sex-matched general population
- Cox proportional hazards models
Main finding
As reported in the abstract
Standard mortality ratio
1.7
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Independent predictors of mortality (multivariate analysis)Older age (per year) | 1.11 (1.07–1.15) | |
| 0.512Hazard ratio (log scale) |
Independent predictors of mortality (multivariate analysis)
| HR (95% CI) | ||
|---|---|---|
| C4 hypocomplementemia | 3.75 (1.55–9.06) | |
| Elevated ESR | 1.01 (1.00–1.03) | |
| History of HF | 4.24 (1.02–17.58) | |
| Pulmonary involvement | 3.31 (1.39–7.88) | |
| 0.050.21520Hazard ratio (log scale) |
Most common causes of death
- Infections
- 35.7%
- Malignancies
- 23.8%
- Cardiovascular disease (CVD)
- 7.1%
Original publication
Mortality in Patients With Sjögren Disease: A Prospective Cohort Study Identifying Key Predictors. J Rheumatol. Published 15 January 2025. doi:10.
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