Sjögren's disease & overlap diseases
Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value
Authors' conclusion
Anti-SS-B without anti-SS-A is exceedingly rare when accurately identified by a rigorous immunological approach. The initial anti-SS-B positivity does not correlate with a specific condition, both at the time of initial identification and after a 26-month follow-up period.
Study context
- Population
- Patients with anti-SS-B positivity (positive in two techniques) and absent anti-SS-A, three hospitals of the Assistance Publique-Hôpitaux de Parisconfirmed isolated anti-SS-B
- Participants
- 61 patients
- Outcome
- Prevalence and diagnostic significance of isolated anti-SS-B antibodies
Methodological detailsmulticentre (three hospitals), descriptive analysis
- Multicentre (three hospitals)
- Descriptive analysis
Main finding
As reported in the abstract
Anti-SS-B positivity among 80 540 requests over 7.9 years
1693
Isolated anti-SS-B in ELISA/addressable laser beam immunoassay (ALBIA)
335
19.8%
Immunodot performed
186
Confirmed isolated anti-SS-B by immunodot (% of anti-SS-B positivity)
61
3.6%
Observational data: associations, not effects.
Further findings
History of autoimmune or autoinflammatory diseases
- Patients with history of various autoimmune or autoinflammatory diseases
- 24 (39.3%)
- New connective tissue disease diagnosed
- 6
New diagnoses during follow-up · median follow-up of 26 months
- New diagnoses
- 2
Original publication
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