Sjögren's disease & overlap diseases
Increased risk of malignancy and osteoporosis in primary Sjögren’s syndrome with thyroid diseases: potential implication from T cells
Main finding · MalignancyResult — go to the resultHazard ratio 4.7 95% CI 1.1–19.3Authors' conclusion
The incidence risk of malignancy and OP was significantly elevated in pSS patients with TD.
Study context
- Population
- Patients diagnosed with pSS admitted between January 2018 and September 2023
- Participants
- 329 patients
- Exposure
- pSS with thyroid disease vs pSS without thyroid disease
- TDn = 109
- Outcome
- Incidence of comorbidities (malignancy and osteoporosis)
Methodological detailsKaplan-Meier and Cox proportional hazards survival analysis, flow cytometry and immunofluorescence of lymphocyte subtypes
- Kaplan-Meier and Cox proportional hazards survival analysis
- Flow cytometry and immunofluorescence of lymphocyte subtypes
Main finding
Malignancy
Hazard ratio
4.7
95% CI 1.1–19.3
P = 0.03
By group
TDvs Without TD
HR 4.7 (95% CI 1.1–19.3); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Further findings
Osteoporosis (OP)
P = 0.03
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Osteoporosis (OP)Independent risk factor | 3.7 (1.3–10.2) | P = 0.01 | |
| 0.050.21520Hazard ratio (log scale) |
Peripheral blood lymphocyte subsets
- Higher ratio of PD1+ subsets of total CD3+ T cells, Th and Tc cells in TD (all P = 0.03)
- Lower ratio of unswitched memory B cells in TD (P = 0.01)
PD1+ Th cells in salivary glands
- Increased in TD vs without TD (P = 0.03) and vs controls (P < 0.01)
Original publication
Increased risk of malignancy and osteoporosis in primary Sjögren’s syndrome with thyroid diseases: potential implication from T cells. Rheumatology (Oxford). Published 13 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →