Sjögren's disease & overlap diseases
Stability of symptom-based subtypes in Sjogren’s disease
Authors' conclusion
NSST subtype membership remains stable over time in a large proportion of patients. When subtype transition is associated with factors at baseline, it is most strongly associated with an uncertain subtype allocation.
Study context
- Population
- Patients with SjD stratified by the Newcastle Sjogren's Stratification Tool (NSST) into four symptom-based subtypes
- Participants
- 274 vs 237
- Exposure
- United Kingdom Primary Sjögren's Syndrome Registry (UKPSSR) cohort vs French Assessment of Systemic Signs and Evolution of Sjogren's Syndrome (ASSESS) cohort
- UKPSSRn = 274
- ASSESSn = 237reference
- Outcome
- Stability of NSST subtype membership over time (retaining subtype)
Methodological detailsindependent comparator cohort, logistic regression
- Independent comparator cohort
- Logistic regression
Main finding
As reported in the abstract
Retention of NSST subtype between two study visits
Subtype membership reasonably stable in both cohorts; proportion retaining subtype
60% and 57%
Observational data: associations, not effects.
Further findings
Retention of the high-symptom burden subtype over time
- High-symptom burden subtype the most stable over time; proportion retaining subtype
- 70% and 67%
Predictors of subtype stability
- Higher baseline probability score the greatest predictor of subtype stability; higher C4 levels, antidepressant use and higher CCI score also predicted increased stability
Original publication
Stability of symptom-based subtypes in Sjogren’s disease. RMD Open. Published 24 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →