Sjögren's disease & overlap diseases
Autonomic dysfunction symptoms in Sjögren’s Disease: A missed dimension linked to disease burden and work disability
An erratum to this article was published (Semin Arthritis Rheum, Dec 2025 ↗)
Authors' conclusion
AD symptoms are not captured by established outcome measures but meaningfully contribute to disease burden and work disability.
Study context
- Population
- Sjögren's Disease (SjD) patients from the Belgian Sjögren's Syndrome Transition Trial
- Participants
- 266 patients
- Exposure
- Low Symptom Burden vs Dryness Dominant with Fatigue vs Pain Dominant with Fatigue (PDF) vs High Symptom Burden (HSB)
- Outcome
- Autonomic dysfunction (AD) symptoms (COMPASS-31) and their association with established SjD outcome measures
Methodological detailscohort from the Belgian Sjögren's Syndrome Transition Trial
- Cohort from the Belgian Sjögren's Syndrome Transition Trial
Main finding
As reported in the abstract
- Anxiety, ρ
- 0.41
- Depression, ρ
- 0.44
- Pain, ρ
- 0.35
- Dryness, ρ
- 0.29
- Fatigue, ρ
- 0.37
Observational data: associations, not effects.
Further findings
Work disability
| OR (95 % CI) | P value | ||
|---|---|---|---|
| COMPASS-31Independent predictor | 2.10 (1.29–3.44) | P < 0.01 | |
| 0.20.5125Odds ratio (log scale) |
COMPASS-31 by symptom-based endotype
- Highest in HSB and PDF (p < 0.001)
COMPASS-31 in premenopausal women with vaginal dryness
- Higher in premenopausal women with vaginal dryness (p < 0.01)
Original publication
Autonomic dysfunction symptoms in Sjögren’s Disease: A missed dimension linked to disease burden and work disability. Semin Arthritis Rheum. Published 17 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →