Sjögren's disease & overlap diseases
Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren’s syndrome
Authors' conclusion
This research indicates that ALFF metrics offer enhanced insights into the alterations of regional brain function in patients with pSS, which exhibits both frequency-dependent and temporal variability characteristics, complementing traditional metrics and enhancing our comprehension of brain function in pSS
Study context
- Population
- Patients with primary Sjögren's syndrome (pSS) and healthy controls undergoing resting-state functional MRI and neuropsychological assessments
- Participants
- 68 vs 69
- Exposure
- pSS vs healthy controls
- pSSn = 68
- Healthy controlsn = 69reference
- Outcome
- Alterations in ALFF, its frequency dependence (slow-5 0.01-0.027 Hz, slow-4 0.027-0.073 Hz) and temporal variability (dALFF)
Methodological detailsresting-state functional MRI, case-control
- Resting-state functional MRI
- Case-control
Main finding
As reported in the abstract
- Right fusiform gyrus abnormal in amplitude of low-frequency fluctuations (ALFF) and both sub-bands in pSS
- Left precentral gyrus and right middle frontal gyrus: abnormal increase limited to slow-5 band
- Dynamic ALFF (dALFF): abnormal activity in left supplementary motor area in pSS
Observational data: associations, not effects.
Further findings
Correlation of slow-5 ALFF differential brain regions with neuropsychological scales
- Correlated with certain neuropsychological scales
Original publication
Frequency-dependent and temporal variability of low-frequency fluctuations in patients with primary Sjögren’s syndrome. Lupus Sci Med. Published 16 September 2025. doi:10.
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