Sjögren's disease & overlap diseases
Ultrasound-guided core needle biopsy of the parotid gland in Sjögren’s disease: a promising tool towards precision medicine
Authors' conclusion
US-guided CNB is safe, well-tolerated and yields adequate tissue.
Study context
- Population
- Patients with Sjögren's disease (SjD) in the Belgian Sjögren's Syndrome Transition Trial (64 of 66 without gland swelling)64 without gland swelling
- Participants
- 66 patients
- Outcome
- Feasibility, safety and tissue adequacy of US-guided CNB of the parotid gland
Methodological detailssingle-group
- Single-group
Main finding
As reported in the abstract
Feasibility, tolerability and tissue adequacy of US-guided CNB of the parotid gland
Mean visual analogue scale (VAS) pain (0–10) during biopsy
2.7
SD=2.77
Mean VAS pain (0–10) in the 3 days before the follow-up call at day 14
1.9
SD=2.33
Patients willing to repeat the procedure
82%
Adequate tissue retrieved
62 of 66
Observational data: associations, not effects.
Further findings
Correlation of histological severity (mild, moderate, severe) with US scores and traditional outcome measures
- Histological severity correlated with US scores
- P < 0.01
- Histological severity did not correlate with ESSPRI dryness or ESSDAI
Safety
- No major complications occurred
Original publication
Ultrasound-guided core needle biopsy of the parotid gland in Sjögren’s disease: a promising tool towards precision medicine. RMD Open. Published 23 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →