Sjögren's disease & overlap diseases
Ultrasound-guided core needle biopsy and incisional biopsy of the parotid gland are comparable in diagnosis of primary Sjögren’s syndrome
Authors' conclusion
US-guided CN biopsy of the parotid gland is at least equivalent to incisional biopsy of the parotid gland in the diagnostic work-up of pSS.
Study context
- Population
- Patients with suspected or confirmed pSS from the Belgian Sjögren's Syndrome Transition Trial (BeSSTT)19 interpretable
- Participants
- 20 patients
- Comparison
- US-guided core needle parotid biopsy vs incisional parotid biopsy
- Outcome
- Concordance between paired biopsies for FS ≥1, germinal centres and lymphoepithelial lesions
Methodological detailsproof-of-concept, paired biopsies, consecutive cohort
- Proof-of-concept
- Paired biopsies
- Consecutive cohort
Performance
As reported in the abstract
Concordance of paired biopsies ≥4 mm²
Concordance for focus score (FS) ≥ 1 (paired biopsies ≥4 mm²)
90%
Patients with ≥4 mm² salivary gland tissue by both techniques
14
Of 3 interpretable incisional biopsies paired with US-guided CN <4 mm², perfect concordance
2 of 3
Further findings
Sensitivity of FS ≥ 1 or germinal centres, including biopsies <4 mm²
Sensitivity
Original publication
Ultrasound-guided core needle biopsy and incisional biopsy of the parotid gland are comparable in diagnosis of primary Sjögren’s syndrome. Rheumatology (Oxford). Published 27 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →