Sjögren's disease & overlap diseases
Kynurenine pathway can be a potential biomarker of fatigue in primary Sjögren's syndrome
Authors' conclusion
Serum markers related to the kynurenine pathway, especially the kynurenine/tryptophan ratio, may be associated with severity of fatigue in pSS.
Study context
- Population
- Patients with Primary Sjögren's syndrome (pSS) from a prospective cohort, and age- and sex-matched healthy controls (HC)
- Participants
- 81 pSS patients
- Exposure
- Severe fatigue vs less fatigue pSS patients vs HC
- Severe fatiguen = 44
- Less fatiguen = 37
- Outcome
- Relationship between severity of fatigue (ESSPRI fatigue domain) and kynurenine pathway serum markers (ELISA)
Methodological detailsprospective cohort, age- and sex-matched healthy controls
- Prospective cohort
- Age- and sex-matched healthy controls
Main finding
As reported in the abstract
Kynurenine pathway markers by fatigue severity
Correlation of kynurenine/tryptophan ratio with fatigue severity in pSS (r)
0.624
Observational data: associations, not effects.
Original publication
Kynurenine pathway can be a potential biomarker of fatigue in primary Sjögren's syndrome. Clin Exp Rheumatol. Published 1 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →