Sjögren's disease & overlap diseases
Anticentromere antibody positive patients with primary Sjögren's syndrome have distinctive clinical and immunological characteristics
Authors' conclusion
ACA positive pSS patients have distinctive clinical manifestations and less severe immunological features, present a lower disease activity and lower activation of the humoral immune system.
Study context
- Population
- Patients with newly diagnosed pSS
- Participants
- 333 patients
- Exposure
- Anticentromere antibody (ACA)-positive vs ACA-negative pSS
- Outcome
- Prevalence of ACA among pSS patients
Methodological detailslogistic regression, multivariate analysis
- Logistic regression
- Multivariate analysis
Main finding
As reported in the abstract
Prevalence of ACA among pSS patients
13.5%
Observational data: associations, not effects.
Original publication
Anticentromere antibody positive patients with primary Sjögren's syndrome have distinctive clinical and immunological characteristics. Clin Exp Rheumatol. Published 24 November 2022. doi:10.
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