Sjögren's disease & overlap diseases
Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren’s disease and non-Sjogren’s sicca
Authors' conclusion
Participants with SjD were less likely to report hirsutism and had lower androstenedione and testosterone pre-menopause when compared with non-SjD sicca.
Study context
- Population
- Newly presenting females investigated for Sjögren's disease (SjD) at a multidisciplinary clinicsteroids in 88 SjD and 59 Sicca samples
- Participants
- 184 participants
- Exposure
- SjD vs non-SjD sicca
- Healthy controlsn = 165
- Outcome
- Hormonal risk factors associated with SjD
Methodological detailsmultidisciplinary clinic, hormonal risk factor questionnaire, liquid chromatography tandem mass spectrometry
- Multidisciplinary clinic
- Hormonal risk factor questionnaire
- Liquid chromatography tandem mass spectrometry
Main finding
As reported in the abstract
SjD vs SiccaOdds ratio (95% CI)P value
History of hirsutism; corrected for smoking status, ethnicity, age and symptom duration
0.14(0.04–0.57)
P = 0.006Hysterectomy up to time of recruitment
3.29(1.19–9.11)
P = 0.02Hysterectomy up to symptom onset
5.8(1.52–22.1)
P = 0.01Observational data: associations, not effects.
Further findings
| Outcome | Androstenedione levels (nmol/l) | P value |
|---|---|---|
| Androstenedione levels by history of hirsutismHirsutism vs No hirsutism | 2.51 vs 1.80 | P = 0.03 |
Androstenedione and testosterone, pre-menopause
- Higher in non-SjD sicca than both SjD and healthy controls
Androstenedione vs minor salivary gland focus score (whole cohort)
- Inverse correlation, r
- −0.44
- P
- P = 0.03
Glucocorticoids
- Lower in both SjD and Sicca vs healthy controls and negatively correlated with symptoms
Original publication
Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren’s disease and non-Sjogren’s sicca. Rheumatology (Oxford). Published 22 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →