Sjögren's disease & overlap diseases
Correlation between colour Doppler activity and parenchymal alterations in salivary glands of patients with primary Sjögren's disease
Authors' conclusion
Colour Doppler ultrasonography reflects inflammatory vascular changes paralleling structural and clinical disease activity in SjD.
Study context
- Population
- Consecutive patients fulfilling the 2016 ACR/EULAR criteria for sjögren's disease (SjD) undergoing standardised salivary gland ultrasonography (SGUS) of parotid and submandibular glands
- Participants
- 63 patients
- Outcome
- Correlation between CD OMERACT ultrasonography score and established B-mode scores (De Vita et al., B-mode OMERACT)
Methodological detailsconsecutive patients, Spearman's rank correlation
- Consecutive patients
- Spearman's rank correlation
Main finding
As reported in the abstract
Correlation of CD OMERACT scores (Spearman's ρ)
- Colour Doppler (CD) OMERACT vs De Vita et al.: moderate correlation, ρ=0.44, p<0.001
- CD OMERACT vs B-mode OMERACT: moderate correlation, ρ=0.48, p<0.001
Observational data: associations, not effects.
Further findings
Correlation of CD OMERACT with glandular ESSDAI (Spearman's ρ)
- CD OMERACT vs glandular ESSDAI: moderate correlation, ρ=0.43, p<0.001
SjD-related lymphoma
- Weak but significant correlation with CD OMERACT and moderate correlation with both B-mode scores
Distribution of SGUS grades
- Most patients had moderate to severe B-mode alterations; higher CD grades (2-3) were less frequent
Original publication
Correlation between colour Doppler activity and parenchymal alterations in salivary glands of patients with primary Sjögren's disease. Clin Exp Rheumatol. Published 22 October 2025. doi:10.
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