Sjögren's disease & overlap diseases
Thirsty eyes: a look at dry eyes in autoimmune/inflammatory syndrome induced by adjuvants
Authors' conclusion
ASIA-BII patients suffer from dry eyes due to impaired tear production. The SSSQ was unable to differentiate SjD patients from ASIA-BII patients, however, biomarkers such as autoantibodies differ between SjD and ASIA-BII patients.
Study context
- Population
- Patients with ASIA-BII, Sjögren's Disease (SjD) and healthy controls from a single centre
- Participants
- 78 / 16 / 17
- Exposure
- ASIA-BII vs SjD vs healthy controls
- ASIA-BIIn = 78
- SjDn = 16
- Healthy controls (HC)n = 17reference
- Outcome
- Impaired tear production (Schirmer test <15mm)
Methodological detailssingle-centre, consecutive enrolment
- Single-centre
- Consecutive enrolment
Main finding
As reported in the abstract
ASIA-BII: impaired tear production (Schirmer test <15mm)
73.1%
ASIA-BII: severe impairment of tear production (Schirmer's test <5mm)
47.4%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Severely impaired tear production, prevalenceASIA-BII vs SjD · similar in prevalence | P = 0.68 |
SSSQ scores and rates of abnormal SSSQ scores
- Similar in ASIA-BII and SjD
Positive ANA, anti-Sjögren Syndrome-A (anti-SSA) and anti-Sjögren Syndrome-B (anti-SSB) antibodies
- Frequency differed between ASIA-BII and SjD
Circulating naive helper T cells, ASIA-BII with severely impaired vs normal tear production (subgroup)
- Reduction with severely impaired tear production
- 0.014
Original publication
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