Sjögren's disease & overlap diseases
Ultra-high frequency ultrasound of labial salivary glands in Sjögren’s disease: diagnostic accuracy and patient stratification
Authors' conclusion
UHFUS of LSGs is a promising diagnostic tool in SjD when biopsy is not feasible.
Study context
- Population
- Patients with suspected Sjögren's disease undergoing ultra-high frequency ultrasound (UHFUS) of labial salivary glands (LSGs)
- Participants
- 270 patients
- Comparison
- UHFUS of labial salivary glands for classification of Sjögren's disease (SjD) vs Sicca
- SjDn = 136
- Siccan = 134reference
- Outcome
- Classification accuracy of UHFUS of LSGs using GS and CD
Performance
As reported in the abstract
Classification accuracy, GS ≥2 (optimal cut-off)
Grey Scale (GS) ≥2 sensitivity
66.2%
GS ≥2 specificity
84.3%
GS Score 3 specificity
98.5%
Further findings
GS in ACR/EULAR criteria in place of biopsy
- AUC
- 0.945
Stratification using GS, GS+colour Doppler (CD) and SSA status
- More than 75% of patients classified with accuracy of 94%
Age-related variability
- GS classification accuracy varied with age, CD remained stable
Original publication
Ultra-high frequency ultrasound of labial salivary glands in Sjögren’s disease: diagnostic accuracy and patient stratification. RMD Open. Published 3 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →