Sjögren's disease & overlap diseases
Predicting lymphoma in Sjögren’s syndrome and the pathogenetic role of parotid microenvironment through precise parotid swelling recording
Authors' conclusion
A more precise clinical recording of PSW can improve lymphoma prediction in pSS. PSW as a very early symptom is a predictor, and a longer duration of PSW is associated with a higher risk of NHL.
Study context
- Population
- Patients with pSS, multicentre
- Comparison
- pSS patients who developed B cell non-Hodgkin's lymphoma (NHL) vs matched pSS controls without NHL
- Outcome
- History of salivary and lachrymal gland swelling (time of onset and duration of PSW) and NHL localization at onset
Methodological detailsmulticentre, matched controls
- Multicentre
- Matched controls
Main finding
As reported in the abstract
PSW frequency
- Parotid swelling (PSW) significantly more frequent among cases at first referred pSS symptoms before diagnosis, at diagnosis and from pSS diagnosis to NHL
- NHL risk increased from PSW of 2-12 months to >12 months (duration from pSS diagnosis)
Observational data: associations, not effects.
Further findings
NHL localization · NHL onset
- NHL prevalently localized in the parotid glands of the cases
Original publication
Predicting lymphoma in Sjögren’s syndrome and the pathogenetic role of parotid microenvironment through precise parotid swelling recording. Rheumatology (Oxford). Published 5 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →