Sjögren's disease & overlap diseases
Association Between Bruton's Tyrosine Kinase Gene Overexpression and Risk of Lymphoma in Primary Sjögren's Syndrome
Authors' conclusion
BTK and APRIL were overexpressed in the peripheral blood of primary SS patients prior to lymphoma.
Study context
- Population
- Well-phenotyped patients with pSS enrolled in the prospective Assessment of Systemic Signs and Evolution in Sjögren's Syndrome (ASSESS) cohort21 with primary SS-NHL
- Participants
- 345 patients
- Comparison
- pSS patients with incident lymphoma vs pSS patients without lymphoma
- I-primary SS-NHLn = 8
- H-primary SS-NHLn = 13
- Without lymphoman = 324reference
- Outcome
- Whole blood gene expression in incident primary SS-NHL vs patients without lymphoma
Methodological detailsprospective cohort (ASSESS), whole blood transcriptomic analysis (Clariom S Arrays), sensitivity analyses, multivariate analysis
- Prospective cohort (ASSESS)
- Whole blood transcriptomic analysis (Clariom S Arrays)
- Sensitivity analyses
- Multivariate analysis
Main finding
As reported in the abstract
Gene expression before lymphoma, incident lymphoma vs without lymphoma
- Bruton's tyrosine kinase (BTK) and a proliferation-inducing ligand (APRIL) genes overexpressed before lymphoma in incident lymphoma vs without lymphoma
- Functional clustering: enrichment of innate and adaptive immunity genes, incl. B cell-related genes
Observational data: associations, not effects.
Further findings
Sensitivity analyses (all primary SS-NHL vs controls stratified on lymphoma risk factors)
- BTK consistently up-regulated across all comparisons
BTK expression and lymphoma risk, multivariate analysis
- BTK expression associated with risk of lymphoma, considering 9 validated predictors
Original publication
Association Between Bruton's Tyrosine Kinase Gene Overexpression and Risk of Lymphoma in Primary Sjögren's Syndrome. Arthritis Rheumatol. Published 28 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →