Sjögren's disease & overlap diseases
Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression
Authors' conclusion
IFN signaling is a hallmark of both HSA and BALS clusters. In BALS, it may drive early disease progression, which can be replaced later by proliferative pathways leading to an HSA.
Study context
- Population
- Patients with sjögren disease (SjD) from the ASSESS cohort (GSE140,161)ASSESS cohort
- Participants
- 351 patients
- Comparison
- Blood transcriptomic signatures across three SjD clusters (BALS, high systemic activity (HSA), LSAHS) and an evolutive BALS subgroup
- Outcome
- Blood transcriptomic signatures and biologic pathways by cluster
Methodological detailsblood transcriptomic analysis, differential expression analysis, Gene Set Enrichment Analysis
- Blood transcriptomic analysis
- Differential expression analysis
- Gene Set Enrichment Analysis
Main finding
As reported in the abstract
- BALS and HSA: robust types I/II interferon (IFN)-stimulated gene up-regulation vs LSAHS
- BALS: stronger IFN activity and inflammatory signaling than HSA, particularly in BALS_Evol
- BALS_Evol: enrichment of IFNα/γ, TNF α, IL-6, complement activation and mechanistic target of rapamycin (mTOR) complex 1 pathways, indicating a hyperinflammatory, dysregulated immune state linked to disease progression
- HSA vs BALS: attenuated IFN and KRAS pathway activity, with activation of MYC, mTOR and oxidative phosphorylation
Original publication
Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression. Arthritis Rheumatol. Published 11 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →