Sjögren's disease & overlap diseases
Molecular classification of primary Sjögren’s syndrome based on salivary gland omics
Study context
- Population
- Patients with pSS; minor salivary gland RNA-seq data
- Comparison
- Classical Immune Type vs Ion Channel Type vs Fibrotic Senescent Type vs Immune Desert Type
- Outcome
- Molecular subtypes of pSS
Methodological detailssingle-cell RNA sequencing and bulk RNA-seq integration, non-negative matrix factorization
- Single-cell RNA sequencing and bulk RNA-seq integration
- Non-negative matrix factorization
Main finding
As reported in the abstract
- Four distinct molecular subtypes identified: Classical Immune, Ion Channel, Fibrotic Senescent and Immune Desert Type
- 4
Further findings
Clinical features and local immune microenvironment profiles per subtype
- Preliminarily characterized for each subtype
Original publication
Molecular classification of primary Sjögren’s syndrome based on salivary gland omics. Arthritis Res Ther. Published 8 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →