Sjögren's disease & overlap diseases
Can ultrasound of the major salivary glands differentiate Sjögren's disease from its major mimics?
Authors' conclusion
This study indicates that SGUS has a potentially high diagnostic accuracy to discriminate SjD from systemic diseases which can also cause salivary gland involvement.
Study context
- Population
- Patients with Sjögren's disease (SjD) and patients with systemic diseases with salivary gland involvement (sarcoidosis, amyloidosis, HIV, chronic HCV)
- Participants
- 20 vs 20
- Comparison
- SGUS in SjD vs other systemic diseases with salivary gland involvement
- SjDn = 20
- Other systemic diseasesn = 20reference
- Outcome
- Diagnostic accuracy of SGUS to differentiate SjD from other diseases with salivary gland involvement
Methodological detailsconsecutive patients, two blinded observers, Hocevar scoring system
- Consecutive patients
- Two blinded observers
- Hocevar scoring system
Performance
As reported in the abstract
Diagnostic accuracy of SGUS (SjD vs other systemic diseases)
AUC
0.91
Optimal cut-off for positive SGUS
15
Sensitivity, specificity, PPV and NPV
85-90%
Diagnostic OR
51
Further findings
| Outcome | SjD | Other systemic diseases | P value |
|---|---|---|---|
| SGUS positive | 18 events | — not stated in the abstract | |
| SGUS scoreSjD vs Other systemic diseases · median | 27 | 10 | P < 0.001 |
| SGUS scoreSjD vs sarcoidosis, amyloidosis, HIV or HCV infection (each) | all p<0.05 |
— not stated in the abstract
- SGUS positive — Positive in patients with HIV infection
- 2
- SGUS positive — Positive in patients with sarcoidosis
- 1
Original publication
Can ultrasound of the major salivary glands differentiate Sjögren's disease from its major mimics? Clin Exp Rheumatol. Published 21 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →