Sjögren's disease & overlap diseases
A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease
Main finding · LymphomaResult — go to the resultOdds ratio 2.60 95% CI 1.14–5.47Authors' conclusion
We found an association between BAFF-var and sBAFF levels, occurrence of lymphoma as well as occurrence of SjD itself.
Study context
- Population
- Patients with Sjögren's disease (SjD) (Paris Saclay and Assessment of Systemic Signs and Evolution in Sjögren's syndrome (ASSESS) cohort) and blood donor controls (EFS); genetic analyses in European ancestry666 cases and 721 controls of European ancestry
- Comparison
- BAFF-var vs BAFF-WT in SjD; SjD cases vs ancestry-matched controls
- Outcome
- Association between BAFF-var and clinical phenotype and risk of SjD
Methodological detailsgenetic association analysis, European ancestry by principal component analysis
- Genetic association analysis
- European ancestry by principal component analysis
Main finding
Lymphoma
Odds ratio
2.60
95% CI 1.14–5.47
By group
BAFF-varvs BAFF-WT
OR 2.60 (95% CI 1.14–5.47)
As reported in the abstract
Observational data: associations, not effects.
Further findings
BAFF-var vs BAFF-WT
sBAFF level
P < 0.001
Cases vs Controls
| Outcome | Cases | Controls | OR | P value |
|---|---|---|---|---|
| BAFF-var minor allele frequency (association with SjD)vs ancestry-matched controls | 0.061 | 0.035 | 1.77 | P = 0.0017 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease. Ann Rheum Dis. Published 14 January 2026. doi:10.
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