Sjögren's disease & overlap diseases
Turkish Society for Rheumatology recommendations for topical and systemic treatments in Sjögren's disease
Methodological detailssystematic literature review, PICO format, expert opinion, 2011 Oxford CEBM levels of evidence, Task force of Turkish specialists in rheumatology, ophthalmology and dentistry; systematic literature review per PRISMA
- Systematic literature review
- PICO format
- Expert opinion
- 2011 Oxford CEBM levels of evidence
- Task force of Turkish specialists in rheumatology, ophthalmology and dentistry; systematic literature review per PRISMA
Recommendations
As issued by the authors
Sicca symptoms: topical therapies are the gold standard (high-level evidence)
Systemic involvement: GC, HCQ and immunosuppressive agents remain cornerstone therapies (evidence mainly case series and clinical experience)
Biologic therapies have limited efficacy in Sjögren's disease (SjD) but may benefit selected subgroups and can be considered in refractory systemic involvement
Original publication
Turkish Society for Rheumatology recommendations for topical and systemic treatments in Sjögren's disease. Clin Exp Rheumatol. Published 7 January 2026. doi:10.
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