Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis
Authors' conclusion
Our findings shed new light on the pathogenesis of JIA
Study context
- Population
- Patients with juvenile idiopathic arthritis (JIA)
- Outcome
- Genes and proteins associated with JIA risk (TWAS/PWAS)
Methodological detailstranscriptome-wide and proteome-wide association studies (TWAS/PWAS), multi-ethnicity HLA typing, single-cell T cell receptor (TCR) repertoire analysis
- Transcriptome-wide and proteome-wide association studies (TWAS/PWAS)
- Multi-ethnicity HLA typing
- Single-cell TCR repertoire analysis
Main finding
As reported in the abstract
- TWAS genes associated with JIA risks
- 19
- PWAS proteins associated with JIA risks
- two
Original publication
Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis. Arthritis Res Ther. Published 10 February 2024. doi:10.
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