Bone microarchitecture impairment in juvenile systemic lupus erythematosus patients: A comparative study
Authors' conclusion
Patients with jSLE exhibited bone microarchitectural impairment, regardless of previous fragility fractures, disease duration, disease activity, or cumulative glucocorticoid exposure.
Study context
- Population
- Patients with Juvenile Systemic Lupus Erythematosus (jSLE) aged 5–19 years; clinical data and bone mineral density (BMD) by DXA 2017–2022, quaternary care center
- Participants
- 50 patients94 examinations
- Exposure
- jSLE patients vs age- and sex-matched healthy Brazilian children and adolescents (published data)
- jSLEn = 50
- Outcome
- TBS values in jSLE vs age- and sex-matched healthy controls
Methodological detailsobservational, analytical, age- and sex-matched comparison with published healthy controls, single-centre (quaternary care center)
- Observational
- Analytical
- Age- and sex-matched comparison with published healthy controls
- Single-centre (quaternary care center)
Main finding
As reported in the abstract
Examinations with significantly lower TBS than age- and sex-matched controls
Examinations with significantly lower Trabecular Bone Score (TBS) values than controls, n (%)
21
22.3%
Observational data: associations, not effects.
Further findings
TBS in female patients aged 14-16 years vs peers
- TBS, female patients aged 14-16 vs peers
- 1.381 vs 1.466
- TBS lower than peers
TBS in female patients aged 17-19 years vs peers
- TBS, female patients aged 17-19 vs peers
- 1.397 vs 1.479
- TBS lower than peers
Concordance and correlation of BMD and TBS
- BMD and TBS concordant, examinations
- 80/94 (85.1%)
- Moderate and positive correlation between BMD and TBS
- P < 0.0001
Correlation of TBS with clinical risk factors and fractures
- No correlation between TBS and previous fractures, disease duration, high disease activity, cumulative GC dose, or fragility fractures
Original publication
Bone microarchitecture impairment in juvenile systemic lupus erythematosus patients: A comparative study. Lupus. Published 18 March 2026. doi:10.
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