Spectrum of clinical phenotypes associated with myositis-specific and myositis-associated antibodies in juvenile idiopathic inflammatory myositis: Our experience from North India
Authors' conclusion
Anti-NXP2 antibody is the most common MSA noted in our North Indian cohort of JIIM.
Study context
- Population
- Children with juvenile idiopathic inflammatory myositis, Pediatric Rheumatology Clinic of a tertiary care referral centre, Chandigarh, North India (1992 to 2024)MSA/MAA assayed in 113
- Participants
- 173 children
- Outcome
- Incidence and clinical-phenotypic profile of MSA/MAA (16-antigen immunoblot)
Methodological detailssingle-centre, tertiary care referral centre
- Single-centre
- Tertiary care referral centre
Main finding
As reported in the abstract
Autoantibody positivity (MSA/MAA)
- Any autoantibody positivity (82/113)
- 72.5%
- MSA positive
- 70
- MAA positive
- 12
- Anti-NXP2 (most common)
- 24
- Anti-MDA5
- 14
- Anti-TIF-1γ
- 12
- Anti-Mi 2
- 9
Observational data: associations, not effects.
Further findings
Phenotype of anti-NXP2-positive patients
- Younger at onset, 3.15 years (1.2-11.88 years)
- P = 0.015
- Severe muscle weakness at onset
- P = 0.04
- Persistent calcinosis in follow-up
- P = 0.004
Phenotype of anti-TIF1γ-positive patients
- Persistent skin lesions during follow-up
- P < 0.001
Phenotype of anti-MDA5 JDM (high incidence)
- Arthritis
- P = 0.001
- Inverse Gottron papules
- P = 0.003
- Skin ulceration
- P = 0.065
- Oral ulcers
- P = 0.012
- ILD
- P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Spectrum of clinical phenotypes associated with myositis-specific and myositis-associated antibodies in juvenile idiopathic inflammatory myositis: Our experience from North India. Semin Arthritis Rheum. Published 17 March 2026. doi:10.
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