Neonatal lupus erythematosus: 24 years of experience from a tertiary centre at Chandigarh, North India
Authors' conclusion
NLE is associated with significant morbidity. More than half had cardiac manifestation, of which 70% had 3rd-degree heart block requiring pacemaker insertion. Other rare clinical manifestations like phrenic nerve palsy and seizures are noticed in our cohort.
Study context
- Population
- Children diagnosed with neonatal lupus erythematosus in a Pediatric Rheumatology Clinic, tertiary care centre, North India, January 1999 - December 2023
- Participants
- 24 children
- Outcome
- Clinical features and laboratory parameters of neonatal lupus erythematosus (NLE)
Methodological detailssingle-centre, tertiary care centre, case record review
- Single-centre
- Tertiary care centre
- Case record review
Main finding
As reported in the abstract
- Median age at diagnosis (days)
- 60
- Male to female ratio
- 1:2
- Cutaneous manifestations
- 14 (58%)
- Hepatomegaly
- 15 (62.5%)
- Splenomegaly
- 2 (8%)
- Elevated transaminases
- 14 (58%)
- Cholestatic jaundice
- 1
- Hematological manifestations
- 20 (83.3%)
- Neurological manifestations
- 8
- Cardiac involvement
- 13 (54%)
- 3rd-degree heart block
- 9
- Epicardial pacemaker insertion
- 6
- Pacemaker reimplantation due to infective endocarditis
- 1
- Congenital hydrops (required respiratory support; uneventful recovery)
- 3
- Transfusions required
- 4
Observational data: associations, not effects.
Original publication
Neonatal lupus erythematosus: 24 years of experience from a tertiary centre at Chandigarh, North India. Lupus. Published 15 December 2024. doi:10.
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